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KMID : 0043319910140010078
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Archives of Pharmacal Research
1991 Volume.14 No. 1 p.78 ~ p.80
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Synthesis and Anti-Inflammatory and Analgesic Activities of 2,4-Di-n-butyl-3,5-diarylimino-1,2,4-thiadiazolidines
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Pandeya SN
Naik PR/Singh S/Singh PN
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Abstract
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Ten 1,2,4-thiadiazolidines were synthesized and screened for their anti-inflammatory and analgesic activities. Butyl isothiocyanate was used as a starting material. Several compounds showed significant anti-inflammatory and analgesic activities. The unsubstituted and o-methyl, p-acetoxy and o-chloro substituted compounds were found to be more potent anti-inflammatory and analgesic agents than the other compounds.
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